![]() ![]() More importantly, these macromolecules possess innate functions and properties due to their unique chemical composition and structure, which increase their bioactivity and therapeutic potential in a wide range of applications. At the same time, these materials have favourable mechanical properties and often considered to be biologically inert. There is an increasing trend in tissue engineering to use natural substrates, such as macromolecules native to plants and animals to improve the biocompatibility and biodegradability of delivered materials. The results of the rheological analysis might be applied for the rational development of cosmetic formulations containing hyaluronic acid of various molecular weights.īiomaterials have had an increasingly important role in recent decades, in biomedical device design and the development of tissue engineering solutions for cell delivery, drug delivery, device integration, tissue replacement, and more. The possibility of using the Ostwald-de Waele equation for the mathematical description of a viscous flow was established. Rheological studies have proved the pseudoplastic nature of the viscous flow of HMW-HA solutions. ![]() Critical values of concentration were determined at different ratios of HMW-HA and LMW-HA, leading to a sharp increase in the viscosity of solutions. HA diluted solutions were found to be weakly structured liquids with a slight viscosity anomaly. Molecular weight and polydispersity of low molecular HA have been determined by matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS). ![]() A real tool for improving and increasing industrial performance, the CIMAG MES Production software suite covers 14 of the business functions defined in the ISA88 / 95 standard.Rheological measurements were carried out on dilute aqueous solutions of high (HMW-HA, 1150 kDa) and low molecular weight hyaluronic acids (LMW-HA, 8 kDa) along with their mixtures to determine the relationship between the viscosity and concentration of the samples. Computerization of workshop production, real-time monitoring of processes, guarantee of product and process traceability, optimization of resources, and digitization of documents are all points that will enable industrialists to achieve operational excellence. This is a great benefit because it enables manufacturers to transform into their factories. Real-time control of production activitiesĬIMAG Production acts as an improvement tool, making it possible to transition into Industry 4.0.Functionally rich, the CIMAG Production software revolves around these four major areas: This process helps improve productivity for manufacturing facilities. This integration allows CIMAG to collect all the data related to production in real time. This software is then integrated with the information system in place (ERP). Alpha-3i promotes the culture of technological innovation by encouraging factories to initiate a transition into Industry 4.0 by implementing MES software.Īlpha-3i’s CIMAG Production MES / MOM software suite is the combination of Manufacturing Operations Management (MOM) and Manufacturing Execution Systems (MES). This company has over 20 years of experience in consulting and integrating MES (Manufacturing Execution System) software. Alpha-3i is a software publisher for the manufacturing industry. ![]()
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